After identifying the patient figures promoted in programmatic documents issued by major authorities intervening in the domain of health, the author examines the case study of a tele-monitoring device and characterizes the instructions materialized or organized for patients, and what the latter do with them to carry out their work (as understood by Strauss et al., 1997). This sheds light on work that is renewed and complexified, yet largely denied and rendered invisible. Support can be found in the interventions of caregivers in charge of telemonitoring, who try to reduce the tension between standardization and singularity, but are constrained by issues surrounding responsibility and the economic model at play. This approach can also be used to investigate forms of partitioning aimed at delimiting areas of responsibility, and how they renew the articulation work required of patients.